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Article

Mutant IDH1 and seizures in patients with glioma.

Neurology - 9 May 2017

Chen Hao, Judkins Jonathon, Thomas Cheddhi, Wu Meijing, Khoury Laith, Benjamin Carolina G, Pacione Donato, Golfinos John G, Kumthekar Priya, Ghamsari Farhad, Chen Li, Lein Pamela, Chetkovich Dane M, Snuderl Matija, Horbinski Craig

Abstract excerpt

OBJECTIVE: Because the d-2-hydroxyglutarate (D2HG) product of mutant isocitrate dehydrogenase 1 (IDH1mut) is released by tumor cells into the microenvironment and is structurally similar to the excitatory neurotransmitter glutamate, we sought to determine whether IDH1mut increases the risk of seizures in patients with glioma, and whether D2HG increases the electrical activity of neurons. METHODS: Three WHO grade...

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Identifiers

PMID: 28404805
DOI: 10.1212/WNL.0000000000003911
PMCID: PMC5419985

Genes

IDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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