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Article

Diagnostic value of plasma and urinary 2-hydroxyglutarate to identify patients with isocitrate dehydrogenase-mutated glioma.

The oncologist - 1 May 2015

Lombardi Giuseppe, Corona Giuseppe, Bellu Luisa, Della Puppa Alessandro, Pambuku Ardi, Fiduccia Pasquale, Bertorelle Roberta, Gardiman Marina Paola, D'Avella Domenico, Toffoli Giuseppe, Zagonel Vittorina

Abstract excerpt

BACKGROUND: Mutant isocitrate dehydrogenase (IDH) 1/2 enzymes can convert α-ketoglutarate into 2-hydroxyglutarate (2HG). The aim of the present study was to explore whether 2HG in plasma and urine could predict the presence of IDH1/2 mutations in patients with glioma. MATERIALS AND METHODS: All patients had histological confirmation of glioma and a recent brain magnetic resonance imaging scan showing the...

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Identifiers

PMID: 25862748
DOI: 10.1634/theoncologist.2014-0266
PMCID: PMC4425377

Genes

IDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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