Article
Postoperative risk of IDH-mutant glioma-associated seizures and their potential management with IDH-mutant inhibitors.
The Journal of clinical investigation - 15 Jun 2023
Drumm Michael R, Wang Wenxia, Sears Thomas K, Bell-Burdett Kirsten, Javier Rodrigo, Cotton Kristen Y, Webb Brynna, Byrne Kayla, Unruh Dusten, Thirunavu Vineeth, Walshon Jordain, Steffens Alicia, McCortney Kathleen, Lukas Rimas V, Phillips Joanna J, Mohamed Esraa, Finan John D, Santana-Santos Lucas, Heimberger Amy B, Franz Colin K, Kurz Jonathan, Templer Jessica W, Swanson Geoffrey T, Horbinski Craig
Abstract excerpt
Seizures are a frequent complication of adult-type diffuse gliomas, and are often difficult to control with medications. Gliomas with mutations in isocitrate dehydrogenase 1 or 2 (IDHmut) are more likely than IDH-wild type (IDHwt) gliomas to cause seizures as part of their initial clinical presentation. However, whether IDHmut is also associated with seizures during the remaining disease course, and whether...
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