Association between accumulation of 2-hydroxyglutarate detected by MR spectroscopy and preoperative seizure in IDH-mutant glioma.

doi:10.3171/2024.6.JNS24166

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Article

Association between accumulation of 2-hydroxyglutarate detected by MR spectroscopy and preoperative seizure in IDH-mutant glioma.

Journal of neurosurgery - 1 Mar 2025

Nagashima Hiroaki, Tanaka Kazuhiro, Yamanishi Shunsuke, Hashiguchi Mitsuru, Iwahashi Hirofumi, Uno Takiko, Somiya Yuichiro, Komatsu Masato, Itoh Tomoo, Sasaki Ryohei, Sasayama Takashi

Abstract excerpt

OBJECTIVE: Epileptic seizures are common in patients with gliomas, and their control represents an important aspect of treatment. The oncometabolite 2-hydroxyglutarate (2HG), produced by mutant isocitrate dehydrogenase (IDH), is thought to be associated with seizures due to its structural similarity to the excitatory neurotransmitter glutamate. Using 3T MR spectroscopy (MRS), the authors investigated whether 2HG...

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Topics

Humans
Glioma
Glutarates
Female
Male
Isocitrate Dehydrogenase

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Middle Aged

Brain Neoplasms

Seizures

Adult

Mutation

Aged

Magnetic Resonance Spectroscopy

Young Adult

Source

Open in PubMed

Identifiers

PMID: 39454209
DOI: 10.3171/2024.6.JNS24166

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