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Article

Association Between IDH1 and IDH2 Mutations and Preoperative Seizures in Patients with Low-Grade Versus High-Grade Glioma: A Systematic Review and Meta-Analysis.

World neurosurgery - 1 Mar 2018

Phan Kevin, Ng Wyatt, Lu Victor M, McDonald Kerrie L, Fairhall Jacob, Reddy Rajesh, Wilson Peter

Abstract excerpt

BACKGROUND: Patients with brain tumors, particularly gliomas, commonly present with seizures. Higher incidence of seizure has been reported in low-grade gliomas and tumors located within the temporal and insular area. The association between IDH1 and IDH2 mutations with preoperative seizures in glioma and the magnitude of this association in low-grade versus high-grade gliomas are unclear. To clarify this...

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Source

Identifiers

PMID: 29288860
DOI: 10.1016/j.wneu.2017.12.112

Genes

IDH1
IDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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