Article
Age-specific mutation profiles and their prognostic implications in pediatric KMT2A-rearranged acute myeloid leukemia.
Haematologica - 1 Apr 2026
Shoji Kota, Yoshida Kenichi, Iyoda Shinju, Ishikawa Moe, Tanaka Miu, Nobe Michidai, Saito Nijika, Shino Yuto, Nannya Yasuhito, Yamato Genki, Tsujimoto Shinichi, Shiba Norio, Hayashi Yasuhide, Shiozawa Yusuke, Shiraishi Yuichi, Chiba Kenichi, Okada Ai, Tanaka Hiroko, Miyano Satoru, Koga Yuhki, Goto Hiroaki, Terui Kiminori, Ito Etsuro, Kiyokawa Nobutaka, Tomizawa Daisuke, Taga Takashi, Moritake Hiroshi, Tawa Akio, Takita Junko, Nishikori Momoko, Adachi Souichi, Ogawa Seishi, Matsuo Hidemasa
Abstract excerpt
Driver mutations in KMT2A-rearranged (KMT2A-r) have been identified in acute myeloid leukemia (AML); however, age-related differences in their frequency and prognostic factors remain unclear. In this study, we report age-specific mutation profiles and outcomes in pediatric patients with KMT2A-r AML. In 239 cases of KMT2A-r AML, infants (<1 year, N= 59) showed a significantly higher event-free survival (EFS) and...
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