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Article

Hematopoietic stem cell transplantation for pediatric acute myeloid leukemia patients with KMT2A rearrangement; A nationwide retrospective analysis in Japan.

Leukemia research - 1 Dec 2019

Miyamura Takako, Kudo Kazuko, Tabuchi Ken, Ishida Hiroyuki, Tomizawa Daisuke, Adachi Souichi, Goto Hiroaki, Yoshida Nao, Inoue Masami, Koh Katsuyoshi, Sasahara Yoji, Fujita Naoto, Kakuda Harumi, Noguchi Maiko, Hiwatari Mitsuteru, Hashii Yoshiko, Kato Koji, Atsuta Yoshiko, Okamoto Yasuhiro

Abstract excerpt

OBJECTIVE: Pediatric acute myeloid leukemia (AML) with KMT2A rearrangement is detected in 15-20% of all pediatric AML patients and is associated with adverse outcomes even after allogeneic hematopoietic stem cell transplantation (HSCT). To investigate outcomes and prognostic factors, we investigated 90 pediatric AML patients with KMT2A rearrangement after allogeneic HSCT. METHODS: We retrospectively analyzed...

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Identifiers

PMID: 31707119
DOI: 10.1016/j.leukres.2019.106263

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