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Updates in KMT2A Gene Rearrangement in Pediatric Acute Lymphoblastic Leukemia

8 Mar 2023

Abstract excerpt

The KMT2A (formerly MLL) encodes the histone lysine-specific N-methyltransferase 2A and is mapped on chromosome 11q23. KMT2A is a frequent target for recurrent translocations in acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), or mixed lineage (biphenotypic) leukemia (MLL). Over 90 KMT2A fusion partners have been identified until now, including the most recurring ones—AFF1, MLLT1, and MLLT3—which...

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PMID: 36979800
DOI: 10.3390/biomedicines11030821

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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