Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Adiposity-Dependent Regulatory Effects on Multi-tissue Transcriptomes.

American journal of human genetics - 1 Sept 2016

Glastonbury Craig A, Viñuela Ana, Buil Alfonso, Halldorsson Gisli H, Thorleifsson Gudmar, Helgason Hannes, Thorsteinsdottir Unnur, Stefansson Kari, Dermitzakis Emmanouil T, Spector Tim D, Small Kerrin S

Abstract excerpt

Obesity is a global epidemic that is causally associated with a range of diseases, including type 2 diabetes and cardiovascular disease, at the population-level. However, there is marked heterogeneity in obesity-related outcomes among individuals. This might reflect genotype-dependent responses to adiposity. Given that adiposity, measured by BMI, is associated with widespread changes in gene expression and...

Topics

Join the communities discussing this publication.

United Kingdom
Absorptiometry, Photon
Adiposity
Datasets as Topic
Intra-Abdominal Fat

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Organ Specificity

Sequence Analysis, RNA

Source

Open in PubMed Open full text

Identifiers

PMID: 27588447
DOI: 10.1016/j.ajhg.2016.07.001
PMCID: PMC5011064

Genes

CHURC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Adiposity-Dependent Regulatory Effects on Multi-tissue Transcriptomes.PMID 27588447Read ↗

BMI-genome interactions regulate global gene expression with emphasis in brain and gut.Semantic proximity Read ↗

A functional genomics pipeline identifies pleiotropy and cross-tissue effects within obesity-associated GWAS loci.Semantic proximity Read ↗

A Complex Network of Obesity-Risk Genes Revealed by Systematic Bioinformatics and Single-Cell Transcriptomic Analyses.Semantic proximity Read ↗

Integrating genetic and transcriptomic data to identify genes underlying obesity risk loci.Semantic proximity Read ↗

Integrative functional genomics and fine-mapping identify regulatory mechanisms of multivariate obesity GWAS and its cardiometabolic implications.Semantic proximity Read ↗

Multifaceted genome-wide study identifies novel regulatory loci for body mass index in IndiansSemantic proximity Read ↗

Inter-Tissue Gene Co-Expression Networks between Metabolically Healthy and Unhealthy Obese IndividualsSemantic proximity Read ↗

Multifaceted genome-wide study identifies novel regulatory loci in SLC22A11 and ZNF45 for body mass index in Indians.Semantic proximity Read ↗

Functional Annotation of GWAS Loci Using Public Transcriptome and Epigenome Datasets Reveals Non-Coding Genes and Regulatory Elements Which May Contribute to BMI.Semantic proximity Read ↗

Harnessing tissue-specific genetic variation to dissect putative causal pathways between body mass index and cardiometabolic phenotypes.Semantic proximity Read ↗

Genetic Regulation of Adipose Gene Expression and Cardio-Metabolic Traits.Semantic proximity Read ↗

Gene expression profile of subcutaneous adipose tissue in BMI-discordant monozygotic twin pairs unravels molecular and clinical changes associated with sub-types of obesitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.