Article

Integrative single-cell characterization of hypothalamus sex-differential and obesity-associated genes and regulatory elements

2022-11-06

Abstract excerpt

Over 500 noncoding genomic loci are associated with obesity. The majority of these loci reside near genes that are expressed in the hypothalamus in specific neuronal subpopulations that regulate food intake, hindering the ability to identify and functionally characterize them. Here, we carried out integrative single-cell analysis (RNA/ATAC-seq) on both mouse and human male and female hypothalamus to characterize g...

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Literature Corpus work: eb5e53db-dea2-5340-8b5a-61ddfb759ae2
DOI: 10.1101/2022.11.06.515311

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