Article

Detecting DNA methylation patterns suggestive of variable escape from X-chromosome inactivation

2026-06-19

Abstract excerpt

The X chromosome is often excluded from studies analyzing associations between traits and DNA methylation. In females, one copy of most genes on the X is inactivated (X-chromosome inactivation; XCI) through DNA methylation of the gene promoter on the inactive X. This leads to challenges in analyzing and interpreting DNA methylation data patterns. Particularly for sex-biased diseases and traits, there may be many l...

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Literature Corpus work: 8bfe28d8-c8f1-55b3-9913-3bb7ad1cca1f
DOI: 10.64898/2026.06.15.732395

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