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Genes that escape X-inactivation in humans have high intraspecific variability in expression, are associated with mental impairment but are not slow evolving.

Molecular biology and evolution - 1 Dec 2013

Zhang Yuchao, Castillo-Morales Atahualpa, Jiang Min, Zhu Yufei, Hu Landian, Urrutia Araxi O, Kong Xiangyin, Hurst Laurence D

Abstract excerpt

In female mammals most X-linked genes are subject to X-inactivation. However, in humans some X-linked genes escape silencing, these escapees being candidates for the phenotypic aberrations seen in polyX karyotypes. These escape genes have been reported to be under stronger purifying selection than other X-linked genes. Although it is known that escape from X-inactivation is much more common in humans than in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24023392
DOI: 10.1093/molbev/mst148
PMCID: PMC3840307

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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