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Article

The antidepressant drug vilazodone is an allosteric inhibitor of the serotonin transporter.

Nature communications - 20 Aug 2021

Plenge Per, Yang Dongxue, Salomon Kristine, Laursen Louise, Kalenderoglou Iris E, Newman Amy H, Gouaux Eric, Coleman Jonathan A, Loland Claus J

Abstract excerpt

Depression is a common mental disorder. The standard medical treatment is the selective serotonin reuptake inhibitors (SSRIs). All characterized SSRIs are competitive inhibitors of the serotonin transporter (SERT). A non-competitive inhibitor may produce a more favorable therapeutic profile. Vilazodone is an antidepressant with limited information on its molecular interactions with SERT. Here we use molecular...

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Source

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Identifiers

PMID: 34417466
DOI: 10.1038/s41467-021-25363-3
PMCID: PMC8379219

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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