Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular mechanism of setron-mediated inhibition of full-length 5-HT3A receptor.

Nature communications - 19 Jul 2019

Basak Sandip, Gicheru Yvonne, Kapoor Abhijeet, Mayer Megan L, Filizola Marta, Chakrapani Sudha

Abstract excerpt

Serotonin receptor (5-HT3AR) is the most common therapeutic target to manage the nausea and vomiting during cancer therapies and in the treatment of irritable bowel syndrome. Setrons, a class of competitive antagonists, cause functional inhibition of 5-HT3AR in the gastrointestinal tract and brainstem, acting as effective anti-emetic agents. Despite their prevalent use, the molecular mechanisms underlying setron...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain Stem
Share to Cryoelectron Microscopy
Share to Gastrointestinal Tract

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Molecular Docking Simulation

Share to Molecular Dynamics Simulation

Share to Receptors, Serotonin, 5-HT3

Share to Serotonin

Share to Xenopus laevis

Source

Open in PubMed Open full text

Identifiers

PMID: 31324772
DOI: 10.1038/s41467-019-11142-8
PMCID: PMC6642186

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular mechanism of setron-mediated inhibition of full-length 5-HT3A receptor.PMID 31324772Read ↗

Interactions of granisetron with an agonist-free 5-HT3A receptor model.Semantic proximity Read ↗

The binding orientations of structurally-related ligands can differ; A cautionary note.Semantic proximity Read ↗

Mapping the molecular motions of 5-HT <sub>3</sub> serotonin-gated channel by Voltage-Clamp FluorometrySemantic proximity Read ↗

Palonosetron-5-HT3 Receptor Interactions As Shown by a Binding Protein Cocrystal Structure.Semantic proximity Read ↗

Cryo-EM reveals the structural basis of subtype-specific, noncompetitive inhibition of the human P2X3 receptorSemantic proximity Read ↗

Ligand recognition and G-protein coupling of trace amine receptor TAAR1.Semantic proximity Read ↗

Structural basis for recognition of anti-migraine drug lasmiditan by the serotonin receptor 5-HT <sub>1F</sub> –G protein complexSemantic proximity Read ↗

Varenicline Interactions at the 5-HT3 Receptor Ligand Binding Site are Revealed by 5-HTBP.Semantic proximity Read ↗

Molecular mechanism of agonism and inverse agonism in ghrelin receptor.Semantic proximity Read ↗

Structural basis of organic cation transporter-3 inhibitionSemantic proximity Read ↗

Pathways and Barriers for Ion Translocation through the 5-HT3A Receptor Channel.Semantic proximity Read ↗

The antidepressant drug vilazodone is an allosteric inhibitor of the serotonin transporter.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.