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Article

Mutational mapping and modeling of the binding site for (S)-citalopram in the human serotonin transporter.

The Journal of biological chemistry - 15 Jan 2010

Andersen Jacob, Olsen Lars, Hansen Kasper B, Taboureau Olivier, Jørgensen Flemming S, Jørgensen Anne Marie, Bang-Andersen Benny, Egebjerg Jan, Strømgaard Kristian, Kristensen Anders S

Abstract excerpt

The serotonin transporter (SERT) regulates extracellular levels of the neurotransmitter serotonin (5-hydroxytryptamine) in the brain by facilitating uptake of released 5-hydroxytryptamine into neuronal cells. SERT is the target for widely used antidepressant drugs, including imipramine, fluoxetine, and (S)-citalopram, which are competitive inhibitors of the transport function. Knowledge of the molecular details...

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Identifiers

PMID: 19892699
DOI: 10.1074/jbc.M109.072587
PMCID: PMC2804362

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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