Article

The Substrate Import Mechanism of the Human Serotonin Transporter

2020-04-10

Abstract excerpt

The serotonin transporter, SERT, initiates the reuptake of extracellular serotonin in the synapse to terminate neurotransmission. Recently, the cryo-EM structures of SERT bound to ibogaine resolved in different states provided the first glimpse of functional conformations at atomistic resolution. However, the conformational dynamics and structural transitions to various intermediate states are not fully understood...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0443931d-494b-5b75-9f7a-cc972c6bf9ef
DOI: 10.26434/chemrxiv.9922301.v2

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The Substrate Import Mechanism of the Human Serotonin TransporterDOI 10.26434/chemrxiv.9922301.v2Read

Unbiased simulations reveal the inward-facing conformation of the human serotonin transporter and Na(+) ion release.Semantic proximity Read

Deep Mutagenesis of a Transporter for Uptake of a Non-Native Substrate Identifies Conformationally Dynamic RegionsSemantic proximity Read

Cholesterol binding to a conserved site modulates the conformation, pharmacology, and transport kinetics of the human serotonin transporter.Semantic proximity Read

Structural basis for recognition of diverse antidepressants by the human serotonin transporter.Semantic proximity Read

Substrate-modulated gating dynamics in a Na+-coupled neurotransmitter transporter homologue.Semantic proximity Read

Atomic-level characterization of conformational transition and substrate binding of xCT transporterSemantic proximity Read

Structural basis for recognition of diverse antidepressants by the human serotonin transporterSemantic proximity Read

Mechanism for alternating access in neurotransmitter transporters.Semantic proximity Read

Fluorescent non-canonical amino acid provides mechanistic insight into the human serotonin transporterSemantic proximity Read

Transmembrane domain 6 of the human serotonin transporter contributes to an aqueously accessible binding pocket for serotonin and the psychostimulant 3,4-methylene dioxymethamphetamine.Semantic proximity Read

Thermal Unfolding of the Human Serotonin Transporter: Differential Effect by Stabilizing and Destabilizing Mutations and Cholesterol on Thermodynamic and Kinetic Stability.Semantic proximity Read

Microseconds simulations reveal a new sodium-binding site and the mechanism of sodium-coupled substrate uptake by LeuT.Semantic proximity Read