Article

Structural basis of substrate transport and drug recognition by the human thiamine transporter SLC19A3

2024-03-11

Abstract excerpt

Thiamine (vitamin B 1 ) functions as an essential coenzyme in cells. Humans and other mammals cannot synthesise this vitamin de novo and thus have to take it up from their diet. Eventually, every cell needs to import thiamine across its plasma membrane which is mainly mediated by two specific thiamine transporters SLC19A2 and SLC19A3. Loss of function mutations in either of these transporters leads to detrimenta...

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Literature Corpus work: 742edf04-5a69-55cf-a478-a5af746ebf1c
DOI: 10.1101/2024.03.11.584396

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