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Article

Structural basis for action by diverse antidepressants on biogenic amine transporters.

Nature - 7 Nov 2013

Wang Hui, Goehring April, Wang Kevin H, Penmatsa Aravind, Ressler Ryan, Gouaux Eric

Abstract excerpt

The biogenic amine transporters (BATs) regulate endogenous neurotransmitter concentrations and are targets for a broad range of therapeutic agents including selective serotonin reuptake inhibitors (SSRIs), serotonin-noradrenaline reuptake inhibitors (SNRIs) and tricyclic antidepressants (TCAs). Because eukaryotic BATs are recalcitrant to crystallographic analysis, our understanding of the mechanism of these...

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Identifiers

PMID: 24121440
DOI: 10.1038/nature12648
PMCID: PMC3904662

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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