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Article

Interaction of antidepressants with the serotonin and norepinephrine transporters: mutational studies of the S1 substrate binding pocket.

The Journal of biological chemistry - 21 Dec 2012

Sørensen Lena, Andersen Jacob, Thomsen Mette, Hansen Stinna M R, Zhao Xiaobei, Sandelin Albin, Strømgaard Kristian, Kristensen Anders S

Abstract excerpt

The serotonin transporter (SERT) and the norepinephrine transporter (NET) are sodium-dependent neurotransmitter transporters responsible for reuptake of released serotonin and norepinephrine, respectively, into nerve terminals in the brain. A wide range of inhibitors of SERT and NET are used as treatment of depression and anxiety disorders or as psychostimulant drugs of abuse. Despite their clinical importance,...

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Identifiers

PMID: 23086945
DOI: 10.1074/jbc.M112.342212
PMCID: PMC3527955

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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