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Structural basis for recognition of anti-migraine drug lasmiditan by the serotonin receptor 5-HT <sub>1F</sub> –G protein complex

2021-05-29

Abstract excerpt

Migraine headache has become global pandemics and is the number one reason of work day loss. The most common drugs for anti-migraine are the triptan class of drugs that are agonists for serotonin receptors 5-HT 1B and 5-HT 1D. However, these drugs have side effects related to vasoconstriction that could have fatal consequences of ischemic heart disease and myocardial infarction. Lasmiditan is a new generation of...

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Literature Corpus work
67af01dd-6432-5eeb-9095-832266a964ee
DOI
10.1101/2021.05.29.446083
Open publication

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Structural basis for recognition of anti-migraine drug lasmiditan by the serotonin receptor 5-HT <sub>1F</sub> –G protein complexDOI 10.1101/2021.05.29.446083
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