Article

Structural basis for recognition of diverse antidepressants by the human serotonin transporter

2017-10-17

Abstract excerpt

<h4>ABSTRACT</h4> Selective serotonin reuptake inhibitors are clinically prescribed antidepressants that act by increasing the local concentration of neurotransmitter at synapses and in extracellular spaces via blockade of the serotonin transporter. Here we report x-ray structures of engineered thermostable variants of the human serotonin transporter bound to the antidepressants sertraline, fluvoxamine, and parox...

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Literature Corpus work: 41706099-2cea-5787-80ba-ba0414d6e148
DOI: 10.1101/204859

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