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Article

Structural basis for recognition of diverse antidepressants by the human serotonin transporter.

Nature structural & molecular biology - 1 Feb 2018

Coleman Jonathan A, Gouaux Eric

Abstract excerpt

Selective serotonin reuptake inhibitors are clinically prescribed antidepressants that act by increasing the local concentrations of neurotransmitters at synapses and in extracellular spaces via blockade of the serotonin transporter. Here we report X-ray structures of engineered thermostable variants of the human serotonin transporter bound to the antidepressants sertraline, fluvoxamine, and paroxetine. The drugs...

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Source

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Identifiers

PMID: 29379174
DOI: 10.1038/s41594-018-0026-8
PMCID: PMC5962350

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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