Article

Chemical and structural investigation of the paroxetine-human serotonin transporter complex

2020-02-27

Abstract excerpt

<h4>ABSTRACT</h4> Antidepressants target the serotonin transporter (SERT) by inhibiting serotonin reuptake. Structural and biochemical studies aiming to understand the binding of small-molecules to conformationally dynamic transporters like SERT often require thermostabilizing mutations and antibodies to stabilize a specific conformation. Such modifications to SERT have led to questions about the relationships of...

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Literature Corpus work: 63a3a07a-11c0-5155-9be9-a4d1874db110
DOI: 10.1101/2020.02.26.966895

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