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Article

Antidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structures.

Nature structural & molecular biology - 1 Jun 2009

Zhou Zheng, Zhen Juan, Karpowich Nathan K, Law Christopher J, Reith Maarten E A, Wang Da-Neng

Abstract excerpt

Sertraline and fluoxetine are selective serotonin re-uptake inhibitors (SSRIs) that are widely prescribed to treat depression. They exert their effects by inhibiting the presynaptic plasma membrane serotonin transporter (SERT). All SSRIs possess halogen atoms at specific positions, which are key...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19430461
DOI: 10.1038/nsmb.1602
PMCID: PMC2758934

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-19430461-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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