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Article

Hematopoietic upstream stimulating factor 1 deficiency is associated with increased atherosclerosis susceptibility in LDL receptor knockout mice.

Scientific reports - 12 Aug 2021

Hoekstra Menno, Ren Baoyan, Laurila Pirkka-Pekka, Hildebrand Reeni B, Soronen Jarkko, Frodermann Vanessa, Li Zhuang, Boon Mariëtte R, Geerling Janine J, Rensen Patrick C N, Jauhiainen Matti, Van Eck Miranda

Abstract excerpt

Total body upstream stimulatory factor 1 (USF1) deficiency in mice is associated with brown adipose tissue activation and a marked protection against the development of obesity and atherosclerotic lesions. Functional expression of USF1 has also been detected in monocytes and monocyte-derived macrophages. In the current study we therefore tested whether selective hematopoietic USF1 deficiency can also beneficially...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34385562
DOI: 10.1038/s41598-021-95858-y
PMCID: PMC8361089

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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