Article
USF1 gene variants, cardiovascular risk, and mortality in European Americans: analysis of two US cohort studies.
Arteriosclerosis, thrombosis, and vascular biology - 1 Dec 2007
Reiner Alexander P, Carlson Christopher S, Jenny Nancy S, Durda J Peter, Siscovick David S, Nickerson Deborah A, Tracy Russell P
Abstract excerpt
OBJECTIVE: A common haplotype of the upstream transcription factor 1 gene (USF1) has been associated with decreased susceptibility to familial combined hyperlipidemia (FCHL) and, paradoxically, with increased risk of cardiovascular disease (CVD) and all-cause mortality. METHODS AND RESULTS: We assessed associations between USF1 tagSNPs, CVD risk factors, and aging-related phenotypes using data from 2 large...
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