Article
Elevating Endogenous Sphingosine-1-Phosphate (S1P) Levels Improves Endothelial Function and Ameliorates Atherosclerosis in Low Density Lipoprotein Receptor-Deficient (LDL-R-/-) Mice.
Thrombosis and haemostasis - 1 Aug 2018
Feuerborn Renata, Besser Manuela, Potì Francesco, Burkhardt Ralph, Weißen-Plenz Gabriele, Ceglarek Uta, Simoni Manuela, Proia Richard L, Freise Hendrik, Nofer Jerzy-Roch
Abstract excerpt
BACKGROUND: Sphingosine-1-phosphate (S1P) is a bioactive lysosphingolipid and a constituent of high-density lipoprotein (HDL) exerting several atheroprotective effects in vitro. However, the few studies addressing anti-atherogenic effects of S1P in vivo have led to disparate results. We here examined atherosclerosis development in low-density lipoprotein receptor (LDL-R)-deficient (LDL-R-/-) mice with elevated...
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