Article
USF1 deficiency activates brown adipose tissue and improves cardiometabolic health.
Science translational medicine - 27 Jan 2016
Laurila Pirkka-Pekka, Soronen Jarkko, Kooijman Sander, Forsström Saara, Boon Mariëtte R, Surakka Ida, Kaiharju Essi, Coomans Claudia P, Van Den Berg Sjoerd A A, Autio Anu, Sarin Antti-Pekka, Kettunen Johannes, Tikkanen Emmi, Manninen Tuula, Metso Jari, Silvennoinen Reija, Merikanto Krista, Ruuth Maija, Perttilä Julia, Mäkelä Anne, Isomi Ayaka, Tuomainen Anita M, Tikka Anna, Ramadan Usama Abo, Seppälä Ilkka, Lehtimäki Terho, Eriksson Johan, Havulinna Aki, Jula Antti, Karhunen Pekka J, Salomaa Veikko, Perola Markus, Ehnholm Christian, Lee-Rueckert Miriam, Van Eck Miranda, Roivainen Anne, Taskinen Marja-Riitta, Peltonen Leena, Mervaala Eero, Jalanko Anu, Hohtola Esa, Olkkonen Vesa M, Ripatti Samuli, Kovanen Petri T, Rensen Patrick C N, Suomalainen Anu, Jauhiainen Matti
Abstract excerpt
USF1 (upstream stimulatory factor 1) is a transcription factor associated with familial combined hyperlipidemia and coronary artery disease in humans. However, whether USF1 is beneficial or detrimental to cardiometabolic health has not been addressed. By inactivating USF1 in mice, we demonstrate protection against diet-induced dyslipidemia, obesity, insulin resistance, hepatic steatosis, and atherosclerosis. The...
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