Article
Potential role of upstream stimulatory factor 1 gene variant in familial combined hyperlipidemia and related disorders.
Arteriosclerosis, thrombosis, and vascular biology - 1 Jun 2012
Auer Simon, Hahne Penelope, Soyal Selma M, Felder Thomas, Miller Karl, Paulmichl Markus, Krempler Franz, Oberkofler Hannes, Patsch Wolfgang
Abstract excerpt
OBJECTIVE: Genetic studies implicated upstream stimulatory factor 1 (USF1) in familial combined hyperlipidemia because the rs2073658 minor allele was associated with reduced risk of familial combined hyperlipidemia and related disorders. The molecular mechanisms whereby rs2073658 influences trait expression have remained elusive. METHODS AND RESULTS: Plasma lipids, rs2073658 genotypes (N=372), and hepatic...
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