Upstream Transcription Factor 1 (USF1) allelic variants regulate lipoprotein metabolism in women and USF1 expression in atherosclerotic plaque.

doi:10.1038/srep04650

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Article

Upstream Transcription Factor 1 (USF1) allelic variants regulate lipoprotein metabolism in women and USF1 expression in atherosclerotic plaque.

Scientific reports - 11 Apr 2014

Fan Yue-Mei, Hernesniemi Jussi, Oksala Niku, Levula Mari, Raitoharju Emma, Collings Auni, Hutri-Kähönen Nina, Juonala Markus, Marniemi Jukka, Lyytikäinen Leo-Pekka, Seppälä Ilkka, Mennander Ari, Tarkka Matti, Kangas Antti J, Soininen Pasi, Salenius Juha Pekka, Klopp Norman, Illig Thomas, Laitinen Tomi, Ala-Korpela Mika, Laaksonen Reijo, Viikari Jorma, Kähönen Mika, Raitakari Olli T, Lehtimäki Terho

Abstract excerpt

Upstream transcription factor 1 (USF1) allelic variants significantly influence future risk of cardiovascular disease and overall mortality in females. We investigated sex-specific effects of USF1 gene allelic variants on serum indices of lipoprotein metabolism, early markers of asymptomatic atherosclerosis and their changes during six years of follow-up. In addition, we investigated the cis-regulatory role of...

Topics

Adult
Alleles
Apolipoproteins B
Atherosclerosis
Cholesterol, LDL
Female
Genotype
Haplotypes
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lipid Metabolism

Male

Plaque, Atherosclerotic

Polymorphism, Single Nucleotide

Prospective Studies

Risk Factors

Sex Factors

Upstream Stimulatory Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 24722012
DOI: 10.1038/srep04650
PMCID: PMC3983598

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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