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Article

Upstream transcription factor 1 influences plasma lipid and metabolic traits in mice

8 Dec 2009

Abstract excerpt

Upstream transcription factor 1 (USF1) has been associated with familial combined hyperlipidemia, the metabolic syndrome, and related conditions, but the mechanisms involved are unknown. In this study, we report validation of Usf1 as a causal gene of cholesterol homeostasis, insulin sensitivity and body composition in mouse models using several complementary approaches and identify associated pathways and gene...

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PMID: 19995791
DOI: 10.1093/hmg/ddp526

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