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Article

Hematopoietic sphingosine 1-phosphate lyase deficiency decreases atherosclerotic lesion development in LDL-receptor deficient mice.

PloS one - 1 Jan 2013

Bot Martine, Van Veldhoven Paul P, de Jager Saskia C A, Johnson Jason, Nijstad Niels, Van Santbrink Peter J, Westra Marijke M, Van Der Hoeven Gerd, Gijbels Marion J, Müller-Tidow Carsten, Varga Georg, Tietge Uwe J F, Kuiper Johan, Van Berkel Theo J C, Nofer Jerzy-Roch, Bot Ilze, Biessen Erik A L

Abstract excerpt

AIMS: Altered sphingosine 1-phosphate (S1P) homeostasis and signaling is implicated in various inflammatory diseases including atherosclerosis. As S1P levels are tightly controlled by S1P lyase, we investigated the impact of hematopoietic S1P lyase (Sgpl1(-/-)) deficiency on leukocyte subsets relevant to atherosclerosis. METHODS AND RESULTS: LDL receptor deficient mice that were transplanted with Sgpl1(-/-) bone...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23700419
DOI: 10.1371/journal.pone.0063360
PMCID: PMC3659045

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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