Article
Hematopoietic NF-kappaB1 deficiency results in small atherosclerotic lesions with an inflammatory phenotype.
Blood - 1 Feb 2004
Kanters Edwin, Gijbels Marion J J, van der Made Ingeborg, Vergouwe Monique N, Heeringa Peter, Kraal Georg, Hofker Marten H, de Winther Menno P J
Abstract excerpt
Atherosclerosis is a chronic inflammatory disease characterized by the accumulation of lipid-laden macrophages in the vessel wall. One of the major transcription factors in inflammation is nuclear factor kappaB (NF-kappaB), and we have studied its role in the development of atherosclerosis. Bone marrow from mice targeted in the NF-kappaB1 gene encoding for the p50 subunit was used to reconstitute irradiated...
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