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Article

Small tandem DNA duplications result from CST-guided Pol α-primase action at DNA break termini.

Nature communications - 10 Aug 2021

Schimmel Joost, Muñoz-Subirana Núria, Kool Hanneke, van Schendel Robin, Tijsterman Marcel

Abstract excerpt

Small tandem duplications of DNA occur frequently in the human genome and are implicated in the aetiology of certain human cancers. Recent studies have suggested that DNA double-strand breaks are causal to this mutational class, but the underlying mechanism remains elusive. Here, we identify a crucial role for DNA polymerase α (Pol α)-primase in tandem duplication formation at breaks having complementary 3' ssDNA...

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Share to DNA Breaks, Double-Stranded
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34376693
DOI: 10.1038/s41467-021-25154-w
PMCID: PMC8355091

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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