Double-strand break end configuration and 3D genome architecture are crucial for chromosomal translocation

Abstract excerpt

Chromosomal translocations originate from erroneous rejoining of DNA double-strand break (DSB) ends and mechanisms of their formation remain largely unknown. Here we reveal DSB end configuration and three-dimensional (3D) genome architecture cooperatively shape both translocation frequency and junctional indel pattern. By integrating multiplex CRISPR/Cas9 editing with an optimized translocation assay, we find that...

Topics

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• CRISPR-Cas Systems
• DNA Breaks, Double-Stranded
• DNA End-Joining Repair
• DNA Repair
• Gene Knockout Techniques
• Mutation
• Tumor Suppressor p53-Binding Protein 1
• Werner Syndrome Helicase

Identifiers and source

Literature Corpus work

abba5009-2433-555e-b501-f4bf955722e9

DOI

10.64898/2026.06.09.731072