Article
Repair-mediated duplication by capture of proximal chromosomal DNA has shaped vertebrate genome evolution.
PLoS genetics - 1 May 2009
Pace John K, Sen Shurjo K, Batzer Mark A, Feschotte Cédric
Abstract excerpt
DNA double-strand breaks (DSBs) are a common form of cellular damage that can lead to cell death if not repaired promptly. Experimental systems have shown that DSB repair in eukaryotic cells is often imperfect and may result in the insertion of extra chromosomal DNA or the duplication of existing DNA at the breakpoint. These events are thought to be a source of genomic instability and human diseases, but it is...
Topics
- Animals
- Base Sequence
- Biometry
- DNA
- DNA Breaks, Double-Stranded
- DNA Repair
- Evolution, Molecular
- Gene Duplication
- Genetic Techniques
- Genetic Variation
- Genome, Human
- Humans
- Models, Genetic
- Polymorphism, Genetic
- Primates