Article

Microhomology-Mediated Tandem Duplication Drives Tandem Repeat Formation Across Life

2026-03-02

Abstract excerpt

Tandem repeats (TR) are common genomic elements that are highly variable and with major functional consequences. Yet, the evolutionary trajectory for their formation remains poorly understood. One proposed mechanism is microhomology-mediated tandem duplication (MTD), in which single-copy DNA segments flanked by microhomology undergo tandem duplication (TD) and can further expand into TRs. Although MTD was first id...

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Literature Corpus work: 6133af93-ff71-5d59-8d88-ea16025a3706
DOI: 10.64898/2026.02.28.708716

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