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Article

Assessment of escape from X chromosome inactivation and gene expression in single human immune cells.

STAR protocols - 17 Sept 2021

Hagen Sven Hendrik, Hennesen Jana, Altfeld Marcus

Abstract excerpt

X-chromosomal genes escaping from X chromosome inactivation (XCI) in immune cells can contribute to sex-specific differences in immune responses. This protocol describes the specific steps to determine escape from XCI and to simultaneously quantify mRNA expression of multiple genes at the single immune cell level using a single-nucleotide polymorphism approach. The protocol furthermore allows the analysis of...

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Identifiers

PMID: 34355200
DOI: 10.1016/j.xpro.2021.100641
PMCID: PMC8319808

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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