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Article

Dissecting OCT4 defines the role of nucleosome binding in pluripotency.

Nature cell biology - 1 Aug 2021

Roberts Gareth A, Ozkan Burak, Gachulincová Ivana, O'Dwyer Michael R, Hall-Ponsele Elisa, Saxena Manoj, Robinson Philip J, Soufi Abdenour

Abstract excerpt

Pioneer transcription factors such as OCT4 can target silent genes embedded in nucleosome-dense regions. How nucleosome interaction enables transcription factors to target chromatin and determine cell identity remains elusive. Here, we systematically dissect OCT4 to show that nucleosome binding is encoded within the DNA-binding domain and yet can be uncoupled from free-DNA binding. Furthermore, accelerating the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34354236
DOI: 10.1038/s41556-021-00727-5
PMCID: PMC7611526

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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