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Repurposed macroH2A Chromatin Landscapes Guide Cellular Reprogramming

2025-12-12

Abstract excerpt

Cellular reprogramming converts differentiated cells into a pluripotent state through extensive chromatin remodeling. The histone variant macroH2A has classically viewed as an epigenetic barrier stabilizing somatic identity and restricting pluripotency gene activation. Here, we show that during reprogramming, macroH2A1 nucleosomes undergo functional repurposing. Early in the process, mH2A1 nucleosomes act as a bar...

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Literature Corpus work
55b78ef1-dc51-5067-97d6-cd1bef768849
DOI
10.64898/2025.12.11.693653
Open publication

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Repurposed macroH2A Chromatin Landscapes Guide Cellular ReprogrammingDOI 10.64898/2025.12.11.693653
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