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Transient pairing of homologous Oct4 alleles accompanies the onset of embryonic stem cell differentiation.

Cell stem cell - 5 Mar 2015

Hogan Megan S, Parfitt David-Emlyn, Zepeda-Mendoza Cinthya J, Shen Michael M, Spector David L

Abstract excerpt

The relationship between chromatin organization and transcriptional regulation is an area of intense investigation. We characterized the spatial relationships between alleles of the Oct4, Sox2, and Nanog genes in single cells during the earliest stages of mouse embryonic stem cell (ESC) differentiation and during embryonic development. We describe homologous pairing of the Oct4 alleles during ESC differentiation...

Topics

Alleles
Animals
Cell Differentiation
Embryonic Stem Cells
Homeodomain Proteins
Mice
Nanog Homeobox Protein
Octamer Transcription Factor-3
Pluripotent Stem Cells
Response Elements
SOXB1 Transcription Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25748933
DOI: 10.1016/j.stem.2015.02.001
PMCID: PMC4355581

Genes

SOX2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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