Article

Nucleosome dynamics of human iPSC during the early stages of neurodevelopment

2018-08-23

Abstract excerpt

Regulation of nucleosome positioning is important for neurodevelopment, and mutation of genes mediating chromatin remodelling are strongly associated with human neurodevelopmental disorders. Unicellular organisms possess arrays of highly positioned nucleosomes within their chromatin, occupying up to 80% of their genomes. These span gene-coding and regulatory regions, and can be associated with local changes of gen...

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Literature Corpus work: 582e4b02-16b8-559b-a136-19e747d38d8e
DOI: 10.1101/398792

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