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Article

Tradeoffs for a viral mutant with enhanced replication speed.

Proceedings of the National Academy of Sciences of the United States of America - 27 Jul 2021

Lanahan Matthew R, Maples Robert W, Pfeiffer Julie K

Abstract excerpt

RNA viruses exist as genetically heterogeneous populations due to high mutation rates, and many of these mutations reduce fitness and/or replication speed. However, it is unknown whether mutations can increase replication speed of a virus already well adapted to replication in cultured cells. By sequentially passaging coxsackievirus B3 in cultured cells and collecting the very earliest progeny, we selected for...

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Identifiers

PMID: 34282021
DOI: 10.1073/pnas.2105288118
PMCID: PMC8325337

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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