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Article

A speed-fidelity trade-off determines the mutation rate and virulence of an RNA virus.

PLoS biology - 1 Jun 2018

Fitzsimmons William J, Woods Robert J, McCrone John T, Woodman Andrew, Arnold Jamie J, Yennawar Madhumita, Evans Richard, Cameron Craig E, Lauring Adam S

Abstract excerpt

Mutation rates can evolve through genetic drift, indirect selection due to genetic hitchhiking, or direct selection on the physicochemical cost of high fidelity. However, for many systems, it has been difficult to disentangle the relative impact of these forces empirically. In RNA viruses, an observed correlation between mutation rate and virulence has led many to argue that their extremely high mutation rates...

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PMID: 29953453
DOI: 10.1371/journal.pbio.2006459
PMCID: PMC6040757

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