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Article

In vitro evolution of high-titer, virus-like vesicles containing a single structural protein

10 Nov 2014

Abstract excerpt

Self-propagating, infectious, virus-like vesicles (VLVs) are generated when an alphavirus RNA replicon expresses the vesicular stomatitis virus glycoprotein (VSV G) as the only structural protein. The mechanism that generates these VLVs lacking a capsid protein has remained a mystery for over 20 years. We present evidence that VLVs arise from membrane-enveloped RNA replication factories (spherules) containing VSV...

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PMID: 25385608
DOI: 10.1073/pnas.1414991111

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