Article
RNA virus mutations and fitness for survival.
Annual review of microbiology - 1 Jan 1997
Domingo E, Holland J J
Abstract excerpt
RNA viruses exploit all known mechanisms of genetic variation to ensure their survival. Distinctive features of RNA virus replication include high mutation rates, high yields, and short replication times. As a consequence, RNA viruses replicate as complex and dynamic mutant swarms, called viral q...
Topics
- Antiviral Agents
- Biological Evolution
- Gene Expression
- Genome, Viral
- Mutation
- RNA Viruses
- RNA, Viral
- Recombination, Genetic
- Virus Diseases
- Virus Replication