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Article

Coxsackievirus B3 mutator strains are attenuated in vivo.

Proceedings of the National Academy of Sciences of the United States of America - 21 Aug 2012

Gnädig Nina F, Beaucourt Stéphanie, Campagnola Grace, Bordería Antonio V, Sanz-Ramos Marta, Gong Peng, Blanc Hervé, Peersen Olve B, Vignuzzi Marco

Abstract excerpt

Based on structural data of the RNA-dependent RNA polymerase, rational targeting of key residues, and screens for Coxsackievirus B3 fidelity variants, we isolated nine polymerase variants with mutator phenotypes, which allowed us to probe the effects of lowering fidelity on virus replication, mut...

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Identifiers

PMID: 22853955
DOI: 10.1073/pnas.1204022109
PMCID: PMC3427060

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-22853955-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

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