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Article

Single-Cell Analysis of RNA Virus Infection Identifies Multiple Genetically Diverse Viral Genomes within Single Infectious Units.

Cell host & microbe - 14 Oct 2015

Combe Marine, Garijo Raquel, Geller Ron, Cuevas José M, Sanjuán Rafael

Abstract excerpt

Genetic diversity enables a virus to colonize novel hosts, evade immunity, and evolve drug resistance. However, viral diversity is typically assessed at the population level. Given the existence of cell-to-cell variation, it is critical to understand viral genetic structure at the single-cell level. By combining single-cell isolation with ultra-deep sequencing, we characterized the genetic structure and diversity...

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Identifiers

PMID: 26468746
DOI: 10.1016/j.chom.2015.09.009
PMCID: PMC4617633

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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