Article
The two faces of mutation: extinction and adaptation in RNA viruses.
IUBMB life - 1 Jan 2000
Elena S F, Miralles R, Cuevas J M, Turner P E, Moya A
Abstract excerpt
From a population standpoint, two main features characterize the replication of RNA viruses and viruses that use RNA as a replicative intermediate: high genetic variability, and enormous fluctuations in population size. Their genetic variability mainly reflects a lack of the proof-reading and post-replicative error correction mechanisms that operate during cellular DNA replication, but recombination and segment...
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