A single amino acid mutation in norovirus NS4 promotes viral spread.

Abstract excerpt

Viruses can rapidly adapt and evolve to new, unfavorable environments due to their decreased replication fidelity, large reproductive index, and short life cycle. Often, these adaptations that enable increased fitness in a new, specialized environment come with a trade-off of decreased fitness in a standard, general environment. Understanding the mechanistic basis for these fitness trade-offs has provided...

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